(R)-Omeprazole (sodium salt)

(R)-Omeprazole is an inhibitor of the gastric H+/K+ ATPase and an enantiomer of esomeprazole (Cay-17303). It inhibits acid secretion induced by histamine (Cay-33828) in isolated rabbit gastric glands (IC50 = 781 µM) to a lesser extent than esomeprazole. (R)-Omeprazole (30 mg/kg) inhibits histamine-induced stomach acid secretions in rats. Formulations containing (R)-omeprazole have been used in the treatment of duodenal and gastric ulcers, gastroesophageal reflux disease (GERD), and erosive esophagitis.Formal Name: 6-methoxy-2-[(R)-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole, monosodium salt. CAS Number: 161796-77-6. Synonyms: (R)-OMEP, (R)-OMP, (R)-OMZ. Molecular Formula: C17H19N3O3S . Na. Formula Weight: 368.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMSO: 5 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 302 nm. SMILES: COC1=CC=C2C(N=C([S@@](CC3=C(C)C(OC)=C(C)C=N3)=O)N2)=C1.[Na]. InChi Code: InChI=1S/C17H19N3O3S.Na/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17,/h5-8H,9H2,1-4H3,(H,19,20),/t24-,/m1./s1. InChi Key: HVAJOLFRLWQQQL-GJFSDDNBSA-N.