(R)-GSK-3685032

Description: (R)-GSK-3685032 is the R-enantiomer of GSK-3685032, a first-in-class, non-time-dependent, non-covalent, reversible, selective DNMT1 inhibitor with an IC50 of 0.036 µM, which induces robust loss of DNA methylation, transcriptional activation, and inhibition of cancer cell growth. Target: Others. Smiles: CCc1c(C#N)c(S[C@@H](C(N)=O)c2ccccc2)nc(N2CCC(N)CC2)c1C#N. References: Adams, Nicholas David, et al. Substituted pyridines as inhibitors of DNMT1 and their preparation. WO2017216727A1.