(R)-Flurbiprofen

(R)-Flurbiprofen is a COX-inactive enantiomer of the racemic non-selective COX inhibitor flurbiprofen (Cay-70250) that has diverse biological activities. It inhibits gamma-secretase activity in vitro and, in vivo, it reduces formation of amyloid-beta peptide 1-42 (Abeta42) and improves axonal transport in young Abeta-plaque free mice but not old mice with existing Abeta plaques in the Tg2576 transgenic model of Alzheimer's disease. (R)-Flurbiprofen inhibits NF-kB activation and DNA binding as well as AP-1 DNA binding in RAW 264.7 macrophages and reduces paw edema in a rat model of zymosan-induced inflammation via COX-independent inhibition of NF-kappaB and AP-1 activation when administered at doses of 1, 3, and 9 mg/kg. It also suppresses prostate tumor cell growth in vitro by inducing p75NTR protein expression and reduces tumor growth and metastasis in multiple mouse models of intestinal neoplasia.Formal Name: (R)-(-)-2-fluoro-alpha-methyl-4-biphenylacetic acid. CAS Number: 51543-40-9. Synonyms: E-7869, Flurizan, Tarenflurbil. Molecular Formula: C15H13FO2. Formula Weight: 244.3. Purity: >99%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 10 mg/ml, Ethanol: 25 mg/ml, PBS (pH 7.2): .9 mg/ml. lambdamax: 247 nm. SMILES: OC(=O)[C@@H](C)c1ccc(c2ccccc2)c(F)c1. InChi Code: InChI=1S/C15H13FO2/c1-10(15(17)18)12-7-8-13(14(16)9-12)11-5-3-2-4-6-11/h2-10H,1H3,(H,17,18). InChi Key: SYTBZMRGLBWNTM-UHFFFAOYSA-N.