Pyridoxal isonicotinoyl hydrazone

Pyridoxal isonicotinoyl hydrazine is a lipophilic, nontoxic, iron-chelating agent that shows high iron chelation efficacy both in vitro in cell culture models and in vivo in rats and mice. Because iron is a crucial component of metabolic pathways involved in DNA synthesis, cancerous cells have a high iron requirement due to rapid rates of proliferation. While pyridoxal isonicotinoyl hydrazine exhibits low anticancer activity, its analogs demonstrate antiproliferative effects in a range of tumor cells.Formal Name: 4-pyridinecarboxylic acid, 2-[[3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinyl]methylene]hydrazide. CAS Number: 737-86-0. Synonyms: NSC 77674, PIH. Molecular Formula: C14H14N4O3. Formula Weight: 286.3. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMF: 1 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.5 mg/ml. SMILES: CC1=NC=C(CO)C(/C=N/NC(C2=CC=NC=C2)=O)=C1O. InChi Code: InChI=1S/C14H14N4O3/c1-9-13(20)12(11(8-19)6-16-9)7-17-18-14(21)10-2-4-15-5-3-10/h2-7,19-20H,8H2,1H3,(H,18,21)/b17-7+. InChi Key: BQYIXOPJPLGCRZ-REZTVBANSA-N.