Pyrantel (pamoate)

Pyrantel is an anthelmintic and agonist of nematode nicotinic acetylcholine receptors (nAChRs). It activates chimeric C. elegans alpha7-nAChRs expressed in BOSC cells (EC50 = 40 µM) and induces contraction of A. suum muscle (EC50 = 57.5 nM). In vitro, pyrantel decreases survival of A. ceylanicum, N. americanus, and T. muris third-stage larvae (IC50s = 90.9, 2, and 95.5 µg/ml, respectively) and N. americanus and T. muris adults (IC50s = 7.6 and 34.1 µg/ml, respectively). In vivo, it decreases intestinal A. ceylanicum burden in hamsters and intestinal H. bakeri burden in mice when administered at a dose of 6 mg/kg. Formulations containing pyrantel have been used in the treatment of parasitic worm infections.Formal Name: 4,4'-methylenebis[3-hydroxy-2-naphthalenecarboxylic acid compd. with 1,4,5,6-tetrahydro-1-methyl-2-[(1E)-2-(2-thienyl)ethenyl]pyrimidine (1:1). CAS Number: 22204-24-6. Synonyms: CP 10423-16. Molecular Formula: C23H16O6 . C11H14N2S. Formula Weight: 594.7. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. lambdamax: 238, 290, 302 nm. SMILES: CN1CCCN=C1/C=C/C2=CC=CS2.OC(C3=CC(C=CC=C4)=C4C(CC5=C(O)C(C(O)=O)=CC6=C5C=CC=C6)=C3O)=O. InChi Code: InChI=1S/C23H16O6.C11H14N2S/c24-20-16(14-7-3-1-5-12(14)9-18(20)22(26)27)11-17-15-8-4-2-6-13(15)10-19(21(17)25)23(28)29,1-13-8-3-7-12-11(13)6-5-10-4-2-9-14-10/h1-10,24-25H,11H2,(H,26,27)(H,28,29),2,4-6,9H,3,7-8H2,1H3/b,6-5+. InChi Key: AQXXZDYPVDOQEE-MXDQRGINSA-N.