Pulegone

Description: 1. Pulegone ((+)-Pulegone) has cytotoxicity followed by regenerative cell proliferation is the MOA for Pulegone-induced urothelial tumors in female rats. 2. Pulegone induces a verapamil-sensitive psychostimulant effect that appears to independ on the opening of L-type calcium channels. 3. Pulegone has negative reinforcing properties and seems to possess anxiolytic-like actions unrelated to the benzodiazepine site of the gamma-aminobutyric acid type A (GABAA) receptor. Target: Calcium Channel, TRP/TRPV Channel, Endogenous Metabolite. Smiles: C[C@@H]1CCC(=C(C)C)C(=O)C1. References: Silveira N S D , Oliveira-Silva G L D , Lamanes B D F , et al. The Aversive, Anxiolytic-Like, and Verapamil-Sensitive Psychostimulant Effects of Pulegone[J]. Biological and Pharmaceutical Bulletin, 2014, 37(5):771-778.