Psoromic Acid

Psoromic acid is an inhibitor of Rab geranylgeranyl transferase (IC50 = 1.3 µM) and P. falciparum fatty acid synthesis (FAS) II. It shows cytotoxic effects on primary rat cerebral cortex and human cancer U87MG cell lines in vitro (IC50s = 79.40 and 56.22 mg/L, respectively). It also is cytotoxic against human KB cancer cells (IC50 = 31.6 µM). It shows moderate activity against liver stage P. beghei (IC50 = 31.6 µM) and drug-resistant blood stage P. falciparum (IC50 = 29.2 µM). The maximum tolerated dose in zebrafish larvae is 15.5 µM.Formal Name: 4-formyl-3-hydroxy-8-methoxy-1,9-dimethyl-11-oxo-11H-dibenzo[b,e][1,4]dioxepin-6-carboxylic acid. CAS Number: 7299-11-8. Synonyms: NSC 92186, Parellic Acid. Molecular Formula: C18H14O8. Formula Weight: 358.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble, Ethanol: Soluble. SMILES: CC1=C(OC)C=C(C(O)=O)C(OC2=C3C(C)=CC(O)=C2C=O)=C1OC3=O. InChi Code: InChI=1S/C18H14O8/c1-7-4-11(20)10(6-19)15-13(7)18(23)26-14-8(2)12(24-3)5-9(17(21)22)16(14)25-15/h4-6,20H,1-3H3,(H,21,22). InChi Key: FUCWJKJZOHOLEO-UHFFFAOYSA-N. Origin: Fungus/Usnea sp..