Pseudolaric Acid B

Pseudolaric acid B (PAB) is a diterpene acid isolated from the bark of P. kaempferi, a traditional Chinese medicinal plant. It has reported antifungal activities, consistent with its traditional use in the treatment of dermatological fungal infections. Moreover, PAB has diverse effects that are relevant to cancer therapy, including inducing apoptosis of cancer cells (IC50 = ~1 µM), preventing angiogenesis, and inhibiting tumor growth in vivo.Formal Name: (3R,4S,4aS,9aR)-4a-(acetyloxy)-3-[(1E,3E)-4-carboxy-1,3-pentadien-1-yl]-3,4,4a,5,6,9-hexahydro-3-methyl-1-oxo-1H-4,9a-ethanocyclohepta[c]pyran-7-carboxylic acid, 7-methyl ester. CAS Number: 82508-31-4. Synonyms: NSC 615488, PAB. Molecular Formula: C23H28O8. Formula Weight: 432.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: Chloroform: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml. lambdamax: 258 nm. SMILES: O=C1[C@@]23[C@@](CCC(C(OC)=O)=CC2)(OC(C)=O)[C@](CC3)([H])[C@](/C=C/C=C(C)/C(O)=O)(C)O1. InChi Code: InChI=1S/C23H28O8/c1-14(18(25)26)6-5-10-21(3)17-9-12-22(20(28)31-21)11-7-16(19(27)29-4)8-13-23(17,22)30-15(2)24/h5-7,10,17H,8-9,11-13H2,1-4H3,(H,25,26)/b10-5+,14-6+/t17-,21+,22+,23-/m0/s1. InChi Key: VDGOFNMYZYBUDT-YDRCMHEVSA-N. Origin: Plant/Pseudolarix amabilis (J. Nelson) Rehd..