PSB-CB5

PSB-CB5 is an antagonist of G protein-coupled receptor GPR18 (IC50 = 0.279 µM). It is 36-, 36-, and 14-fold selective for GPR18 over GPR55, cannabinoid 1 (CB1), and CB2 receptors, respectively. PSB-CB5 (1 µM) inhibits acrosomal exocytosis induced by the endogenous GPR18 ligand arachidonoyl glycine (NAGly, Cay-90051) in human spermatozoa.Formal Name: (2Z)-2-[[3-[(4-chlorophenyl)methoxy]phenyl]methylene]-6,7-dihydro-5H-imidazo[2,1-b][1,3]thiazin-3(2H)-one. CAS Number: 1627710-30-8. Synonyms: CID-85469571. Molecular Formula: C20H17ClN2O2S. Formula Weight: 384.9. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: up to 25mg/mL. lambdamax: 220, 251, 378 nm. SMILES: O=C1N2C(SCCC2)=N/C1=C\C3=CC(OCC4=CC=C(C=C4)Cl)=CC=C3. InChi Code: InChI=1S/C20H17ClN2O2S/c21-16-7-5-14(6-8-16)13-25-17-4-1-3-15(11-17)12-18-19(24)23-9-2-10-26-20(23)22-18/h1,3-8,11-12H,2,9-10,13H2/b18-12-. InChi Key: XJBQRMOGMULGPP-PDGQHHTCSA-N.