Protocatechuic Acid

Protocatechuic acid (PCA) is a dihydroxybenzoic acid phenolic compound found in many edible and medicinal plants. It is a major metabolite of antioxidant polyphenols found in green tea and demonstrates free radical scavenging capability in a 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity assay (IC50 = 16.3 µM). It is thought to possess anti-inflammatory, antihyperglycemic, neuroprotective, and anticancer activities. Dietary administration of PCA dose dependently inhibits in vitro chemical carcinogenesis and exerts pro-apoptotic and anti-proliferative effects in different tissues. In studies of tumor cell migration and invasion using mouse melanoma B16/F10 cells, PCA at 0.1-2 mM down-regulated the Ras/Akt/NF-kappaB pathway by targeting RhoB activation, leading to a reduction of MMP-mediated activity.Formal Name: 3,4-dihydroxy-benzoic acid. CAS Number: 99-50-3. Synonyms: NSC 16631, PCA. Molecular Formula: C7H6O4. Formula Weight: 154.1. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 16.7 mg/ml, Ethanol: 16.7 mg/ml, PBS (pH 7.2): 0.14 mg/ml. lambdamax: 220, 260, 296 nm. SMILES: OC1=CC=C(C(O)=O)C=C1O. InChi Code: InChI=1S/C7H6O4/c8-5-2-1-4(7(10)11)3-6(5)9/h1-3,8-9H,(H,10,11). InChi Key: YQUVCSBJEUQKSH-UHFFFAOYSA-N. Origin: Synthetic.