Probenecid

Probenecid
Artikelnummer Größe Datenblatt Manual SDB Lieferzeit Menge Preis
Cay14981-5 5 g -

6 - 10 Werktage*

43,00 €
Cay14981-10 10 g -

6 - 10 Werktage*

65,00 €
Cay14981-25 25 g -

6 - 10 Werktage*

115,00 €
Cay14981-100 100 g -

6 - 10 Werktage*

409,00 €
 
Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) and the... mehr
Produktinformationen "Probenecid"
Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) and the ATP-binding cassette transporter (ABCC1) multidrug resistance protein 1 (MRP1) and activates the transient receptor potential (TRP) channel TRPV2. It inhibits OAT1, OAT3, and OAT6 (Kis = 6.3, 9.0, and 8.4 µM, respectively), as well as OAT2 (IC50 = 0.67 µM), and is selective for OATs over organic cation transporter 1 (OCT1) and OCT2 (IC50s = 1,600 and 1,700 µM, respectively). Probenecid (7 mM) decreases Fas antibody-induced glutathione (GSH) efflux and staurosporine-induced efflux of the MRP1 substrate calcein in Jurkat cells and decreases apoptotic progression. It is an agonist of TRPV2 (EC50 = 31.9 µM). It induces nociceptive behavior in mouse models of carrageenan- or complete Freund's adjuvant-induced inflammatory pain when administered at a dose of 20 mM in drinking water in combination with doses of carrageenan or CFA that do not provoke pain responses alone. Formulations containing probenecid have been used in the treatment of gouty arthritis.Formal Name: 4-[(dipropylamino)sulfonyl]-benzoic acid. CAS Number: 57-66-9. Synonyms: NSC 18786. Molecular Formula: C13H19NO4S. Formula Weight: 285.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.15 mg/ml, Ethanol: 10 mg/ml. lambdamax: 224, 249 nm. SMILES: O=C(O)C1=CC=C(S(N(CCC)CCC)(=O)=O)C=C1. InChi Code: InChI=1S/C13H19NO4S/c1-3-9-14(10-4-2)19(17,18)12-7-5-11(6-8-12)13(15)16/h5-8H,3-4,9-10H2,1-2H3,(H,15,16). InChi Key: DBABZHXKTCFAPX-UHFFFAOYSA-N.
Schlagworte: NSC 18786, 4-[(dipropylamino)sulfonyl]-benzoic acid
Hersteller: Cayman Chemical
Hersteller-Nr: 14981

Eigenschaften

Anwendung: Uricosuric, organic anion transporter inhibitor
MW: 285.4 D
Formel: C13H19NO4S
Reinheit: >98%
Format: Crystalline Solid

Datenbank Information

CAS : 57-66-9| Passende Produkte
KEGG ID : K08216 | Passende Produkte

Handhabung & Sicherheit

Lagerung: -20°C
Versand: +20°C (International: -20°C)
Signalwort: Warning
GHS-Piktogramme:
H-Sätze: H302
P-Sätze: P264, P270, P330, P301+P310, P501
Achtung
Nur für Forschungszwecke und Laboruntersuchungen: Nicht für die Anwendung im oder am Menschen!
Hier kriegen Sie ein Zertifikat
oder , um Analysenzertifikate anzufordern.
Bewertungen lesen, schreiben und diskutieren... mehr
Kundenbewertungen für "Probenecid"
Bewertung schreiben
oder , um eine Produktbewertung abzugeben.
Zuletzt angesehen