Pristinamycin IA

Description: Pristinamycin IA (Mikamycin B) is a cyclo-peptidic macrolactone antibiotic and a substrate for the P-glycoprotein. Target: Antibiotic, P-gp, Others. Smiles: [H][C@@]12CCCN1C(=O)[C@H](CC)NC(=O)[C@@H](NC(=O)c1ncccc1O)[C@H](C)OC(=O)[C@@]([H])(NC(=O)[C@]1([H])CC(=O)CCN1C(=O)[C@H](Cc1ccc(cc1)N(C)C)N(C)C2=O)c1ccccc1. References: Phung-Ba V et al. Interaction of pristinamycin IA with P-glycoprotein in human intestinal epithelial cells. Eur J Pharmacol. 1995 Jan 16,288(2):187-92.