Pregnenolone Carbonitrile

Description: Pregnenolone Carbonitrile (5-Pregnen-3beta-ol-20-one-16alpha-carbonitrile) is an activator of rodent-PXR and induces the expression of CYP3A. Target: P450. Smiles: [H][C@@]12C[C@@H](C#N)[C@H](C(C)=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@@H](O)CC[C@]12C. References: Carylyn J Marek, et al. Pregnenolone-16alpha-carbonitrile inhibits rodent liver fibrogenesis via PXR (pregnane X receptor)-dependent and PXR-independent mechanisms. Biochem J. 2005 May 1,387(Pt 3):601-8.