PQA-18

A PAK2 inhibitor (IC50 = 10 nM) and an immunosuppressant, inhibits concanavalin A-induced production of IL-2 in Jurkat T cells (IC50 = 400 nM), decreases disease severity, serum IgE levels, and skin thickness in the NC/Nga mouse model of atopic dermatitis when applied topically at 0.1%, reduces cutaneous nerve fiber density in NC/Nga mice when applied topically at 0.05%, increases graft survival rate in a rat model of small intestine transplant at 4 mg/kg. Formulation: A powder. InChI: InChI=1S/C25H31NO4/c1-17(2)10-13-28-22-9-7-8-20-23(29-14-11-18(3)4)16-21(26-24(20)22)25(27)30-15-12-19(5)6/h7-12,16H,13-15H2,1-6H3. InChIKey: APPXFGJVXDYNBO-UHFFFAOYSA-N. SMILES: C/C(C)=C/COC1=C(C=CC=C2OC/C=C(C)\C)C2=NC(C(OC/C=C(C)/C)=O)=C1