POMHEX

POMHEX is a prodrug form of the beta-enolase, also known as enolase-3, inhibitor HEX. It is converted to HEX by intracellular carboxylesterases and selectively reduces the cell density of ENO1-/- D-423MG glioblastoma cells (IC50 = 38 nM) over ENO1-overexpressing D-423MG cells and LN-319 astrocytoma cells expressing wild-type ENO1 (IC50s = 604 and 2,148 nM, respectively). POMHEX decreases cell density in normoxic and hypoxic growth conditions in ENO1-/- D-423MG cells (IC50s = 79 and 201 nM, respectively).Formal Name: 2,2-dimethyl-propanoic acid, 1,1'-[[(1-hydroxy-2-oxo-3-piperidinyl)phosphinylidene]bis(oxymethylene)] ester. CAS Number: 2004714-34-3. Molecular Formula: C17H30NO9P. Formula Weight: 423.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: O=C(C(C)(C)C)OCOP(OCOC(C(C)(C)C)=O)(C1C(N(CCC1)O)=O)=O. InChi Code: InChI=1S/C17H30NO9P/c1-16(2,3)14(20)24-10-26-28(23,12-8-7-9-18(22)13(12)19)27-11-25-15(21)17(4,5)6/h12,22H,7-11H2,1-6H3. InChi Key: TVFIFFUSHZDTKT-UHFFFAOYSA-N.