Podocarpusflavone A

Podocarpusflavone A is a biflavone that has been found in D. araucarioides and has diverse biological activities. It inhibits dengue virus NS5 RNA-dependent RNA polymerase (DENV-NS5 RdRp, IC50 = 0.75 µM). Podocarpusflavone A also inhibits cathepsin B with an IC50 value of 1.68 µM and inhibits STAT3 in a reporter assay in a concentration-dependent manner. It reduces the production of reactive oxygen species (ROS) and superoxide anions induced by phorbol 12-myristate 13-acetate (PMA, Cay-10008014) in isolated human neutrophils when used at concentrations of 1 and 10 µM, respectively. Podocarpusflavone A also inhibits aggregation of amyloid-beta (1-40) peptide (Abeta40, Cay-21617) in a cell-free assay with an IC50 value of 4.9 µM. Podocarpusflavone A (20 µM) decreases viability of A375, MALME-3M, SK-MEL-1, and SK-MEL-5 melanoma cells and reduces tumor growth in an A375 mouse xenograft model when administered at doses of 20 and 40 mg/kg.Formal Name: 8-[5-(5,7-dihydroxy-4-oxo-4H-1-benzopyran-2-yl)-2-hydroxyphenyl]-5,7-dihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 22136-74-9. Synonyms: PCFA. Molecular Formula: C31H20O10. Formula Weight: 552.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble, Ethanol: soluble. lambdamax: 272, 334 nm. SMILES: O=C1C=C(C2=CC(C3=C(C=C(C4=C3OC(C5=CC=C(OC)C=C5)=CC4=O)O)O)=C(O)C=C2)OC6=C1C(O)=CC(O)=C6. InChi Code: InChI=1S/C31H20O10/c1-39-17-5-2-14(3-6-17)25-13-24(38)30-22(36)11-21(35)28(31(30)41-25)18-8-15(4-7-19(18)33)26-12-23(37)29-20(34)9-16(32)10-27(29)40-26/h2-13,32-36H,1H3. InChi Key: RBTRUVNXLDXHBJ-UHFFFAOYSA-N. Origin: Plant/Selaginella.