Picroside I

Picroliv is a hepatoprotective mixture of compounds that is isolated from an herb native to the Himalayas. Picroside I is an iridoid glycoside found in picroliv. By itself, picroside I blocks changes in acid phosphatase activity, phospholipid levels, and lipid peroxide production induced by D-galactosamine in rat liver. Picroside I also enhances neurite outgrowth in PC12D cells induced by basic fibroblast growth factor and 7S nerve growth factor when given at 60 µM. At concentrations as low as 5 µM, picroside I enhances the ATPase activity of the efflux transporter P-glycoprotein.Formal Name: 6-[(2E)-3-phenyl-2-propenoate]-1aS,1bS,2S,5aR,6S,6aS-hexahydro-6-hydroxy-1a-(hydroxymethyl)oxireno[4,5]cyclopenta[1,2-c]pyran-2-yl-beta-D-glucopyranoside. CAS Number: 27409-30-9. Synonyms: 6'-Cinnamoylcatalpol. Molecular Formula: C24H28O11. Formula Weight: 492.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 10 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 216, 222, 276 nm. SMILES: O=C(/C=C/C1=CC=CC=C1)OC[C@@H]2[C@@H](O)[C@H](O)[C@@H](O)[C@@](O[C@H]3[C@@]([C@]4(CO)[C@@H](O4)[C@H]5O)([H])[C@@]5([H])C=CO3)([H])O2. InChi Code: InChI=1S/C24H28O11/c25-11-24-16-13(17(27)21(24)35-24)8-9-31-22(16)34-23-20(30)19(29)18(28)14(33-23)10-32-15(26)7-6-12-4-2-1-3-5-12/h1-9,13-14,16-23,25,27-30H,10-11H2/b7-6+/t13-,14-,16-,17+,18-,19+,20-,21+,22+,23+,24-/m1/s1. InChi Key: XZGPUOQGERGURE-LUVHZPKESA-N.