Pibrentasvir

Pibrentasvir is an inhibitor of hepatitis C virus (HCV) non-structural protein 5A (NS5A). It inhibits HCV replication in stable replicon cell lines containing NS5A from genotypes 1-6 (EC50s = 1.4-4.3 pM). Pibrentasvir acts synergistically with the HCV NS3/4A protease inhibitor glecaprevir to inhibit HCV genotype 1b-Con1 replication in replicon cells. Formulations containing pibrentasvir have been used in combination with glecaprevir in the treatment of HCV infection.Formal Name: N,N'-[[(2R,5R)-1-[3,5-difluoro-4-[4-(4-fluorophenyl)-1-piperidinyl]phenyl]-2,5-pyrrolidinediyl]bis[(6-fluoro-1H-benzimidazole-5,2-diyl)-(2S)-2,1-pyrrolidinediyl[(1S)-1-[(1R)-1-methoxyethyl]-2-oxo-2,1-ethanediyl]]]bis-carbamic acid, dimethyl ester. CAS Number: 1353900-92-1. Molecular Formula: C57H65F5N10O8. Formula Weight: 1113.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 25 mg/ml, DMSO: 20 mg/ml, Ethanol: 10 mg/ml. lambdamax: 252, 284 nm. SMILES: FC1=C(N2CCC(C3=CC=C(F)C=C3)CC2)C(F)=CC(N4[C@@H](C5=C(F)C=C(NC([C@@H]6CCCN6C([C@H]([C@H](OC)C)NC(OC)=O)=O)=N7)C7=C5)CC[C@@H]4C8=CC(N=C([C@H]9N(C([C@H]([C@H](OC)C)NC(OC)=O)=O)CCC9)N%10)=C%10C=C8F)=C1. InChi Code: InChI=1S/C57H65F5N10O8/c1-29(77-3)49(67-56(75)79-5)54(73)70-19-7-9-47(70)52-63-41-25-35(37(59)27-43(41)65-52)45-15-16-46(72(45)34-23-39(61)51(40(62)24-34)69-21-17-32(18-22-69)31-11-13-33(58)14-12-31)36-26-42-44(28-38(36)60)66-53(64-42)48-10-8-20-71(48)55(74)50(30(2)78-4)68-57(76)80-6/h11-14,23-30,32,45-50H,7-10,15-22H2,1-6H3,(H,63,65)(H,64,66)(H,67,75)(H,68,76)/t29-,30-,45-,46-,47+,48+,49+,50+/m1/s1. InChi Key: VJYSBPDEJWLKKJ-NLIMODCCSA-N.