Phorbol

Phorbol is a diterpene originally isolated from croton oil. It is used as a starting material for the semisynthesis of various phorbol diesters, which are structurally analogous to diacylglycerol and activate PKC isoforms by associating with their C1 domains.Formal Name: (1aR,1bS,4aR,7aS,7bS,8R,9R,9aS)-1,1a,1b,4,4a,7a,7b,8,9,9a-decahydro-4a,7b,9,9a-tetrahydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one. CAS Number: 17673-25-5. Synonyms: NSC 154778, (+)-Phorbol. Molecular Formula: C20H28O6. Formula Weight: 364.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: slightly soluble, PBS (pH 7.2): 1 mg/ml. lambdamax: 230 nm. SMILES: OCC1=C[C@]2([H])[C@]([C@@](C=C(C)C3=O)([H])[C@]3(O)C1)(O)[C@H](C)[C@@H](O)[C@]4(O)[C@H]2C4(C)C. InChi Code: InChI=1S/C20H28O6/c1-9-5-13-18(24,15(9)22)7-11(8-21)6-12-14-17(3,4)20(14,26)16(23)10(2)19(12,13)25/h5-6,10,12-14,16,21,23-26H,7-8H2,1-4H3/t10-,12+,13-,14-,16-,18-,19-,20-/m1/s1. InChi Key: QGVLYPPODPLXMB-UBTYZVCOSA-N.