Phenethyl isothiocyanate

Phenethyl isothiocyanate (PEITC) is an isothiocyanate that has been found in cruciferous vegetables and has anticancer activity. It inhibits the activity of glutathione peroxidase (GPX), reduces cellular glutathione (GSH) levels, and induces the accumulation of reactive oxygen species (ROS) in T72 ovarian epithelial cells expressing H-RasV12 when used at a concentration of 10 µM. PEITC (10 µM) induces cell cycle arrest at the G2/M phase and apoptosis in PL45, MIA PaCa-2, and BxPC-3 pancreatic cancer cells. It decreases the number of tumor cells expressing Ki-67 or proliferating cell nuclear antigen (PCNA), markers of cell proliferation, and reduces tumor growth in a MIA PaCa-2 mouse xenograft model.Formal Name: (2-isothiocyanatoethyl)-benzene. CAS Number: 2257-09-2. Synonyms: NSC 87868, PEITC. Molecular Formula: C9H9NS. Formula Weight: 163.2. Purity: >95%. Formulation: (Request formulation change), A liquid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. SMILES: S=C=NCCC1=CC=CC=C1. InChi Code: InChI=1S/C9H9NS/c11-8-10-7-6-9-4-2-1-3-5-9/h1-5H,6-7H2. InChi Key: IZJDOKYDEWTZSO-UHFFFAOYSA-N. Origin: Synthetic.