PF-750

Fatty acid amide hydrolase (FAAH) is the enzyme responsible for hydrolysis and inactivation of fatty acid amides including anandamide and oleamide. PF-750 is a potent, time-dependent, irreversible FAAH inhibitor with IC50 values of 0.6 and 0.016 µM when preincubated with recombinant human FAAH for 5 and 60 minutes, respectively. Activity-based profiling of various human and murine tissue proteome samples revealed that PF-750 is highly selective for FAAH relative to other serine hydrolases, showing no discernable off-site activity up to 500 µM.Formal Name: N-phenyl-4-(quinolin-2-ylmethyl)piperidine-1-carboxamide. CAS Number: 959151-50-9. Molecular Formula: C22H23N3O. Formula Weight: 345.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 20 mg/ml, DMSO:PBS (pH 7.2) (1:5): 0.125 mg/ml, Ethanol: 1 mg/ml. lambdamax: 206, 234 nm. SMILES: O=C(Nc1ccccc1)N1CCC(CC1)Cc1cnc2ccccc2c1. InChi Code: InChI=1S/C22H23N3O/c26-22(24-20-7-2-1-3-8-20)25-12-10-17(11-13-25)14-18-15-19-6-4-5-9-21(19)23-16-18/h1-9,15-17H,10-14H2,(H,24,26). InChi Key: BIODYGOZWZNCAG-UHFFFAOYSA-N.