PF-04859989 HCl

Description: PF-04859989 HCl is a brain-penetrable and irreversible inhibitor of kynurenine amino transferase II (KAT II), which is the enzyme responsible for most of the brain synthesis of kynurenic acid. Target: Others. Smiles: Cl.N[C@H]1Cc2ccccc2N(O)C1=O. References: Nematollahi A, Sun G, Jayawickrama GS, Hanrahan JR, Church WB. Study of the Activity and Possible Mechanism of Action of a Reversible Inhibitor of Recombinant Human KAT-2: A Promising Lead in Neurodegenerative and Cognitive Disorders. Molecules. 2016 Jun 29,21(7). pii: E856. doi: 10.3390/molecules21070856. PubMed PMID: 27367665.