Peramivir

Peramivir is an inhibitor of influenza neuraminidase (IC50s = 0.09 and 11 nM for influenza A and B neuraminidases, respectively). It is selective for influenza neuraminidase over bacterial, mammalian, and other viral neuraminidases (IC50s = >300 µM). Peramivir inhibits neuraminidase activity in H1N1, H2N2, H3N2, and H6N2 influenza strains (IC50s = 0.09-1.1 nM) and reduces lysis of MDCK cells infected with influenza (EC50s = <0.01-21 nM). Pretreatment with peramivir (10-100 mg/kg) protects mice against lethal influenza infections. It also increases survival in ferrets infected intranasally with avian influenza type A H5N1 when injected intramuscularly after infection. Formulations containing peramivir have been used to treat influenza.Formal Name: (1S,2S,3R,4R)-3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(aminoiminomethyl)amino]-2-hydroxy-cyclopentanecarboxylic acid. CAS Number: 330600-85-6. Synonyms: BCX 1812, RWJ 270201. Molecular Formula: C15H28N4O4. Formula Weight: 328.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. SMILES: OC([C@H]1C[C@@H](NC(N)=N)[C@@]([C@@H](NC(C)=O)C(CC)CC)([H])[C@@H]1O)=O. InChi Code: InChI=1S/C15H28N4O4/c1-4-8(5-2)12(18-7(3)20)11-10(19-15(16)17)6-9(13(11)21)14(22)23/h8-13,21H,4-6H2,1-3H3,(H,18,20)(H,22,23)(H4,16,17,19)/t9-,10+,11+,12-,13+/m0/s1. InChi Key: XRQDFNLINLXZLB-CKIKVBCHSA-N.