PC190723

An inhibitor of bacterial FtsZ, active against B. subtilis, S. epidermidis, S. hemolyticus, and S. aureus, including MRSA and MDRSA (MICs = 0.5-1 µg/ml), increases survival in a mouse model of lethal S. aureus infection at 10 and 30 mg/kg. Formulation: A crystalline solid. InChI: InChI=1S/C14H8ClF2N3O2S/c15-6-3-8-14(19-4-6)23-10(20-8)5-22-9-2-1-7(16)11(12(9)17)13(18)21/h1-4H,5H2,(H2,18,21). InChIKey: INYJNSBDHOVLAH-UHFFFAOYSA-N. SMILES: FC1=C(OCC2=NC(C=C(Cl)C=N3)=C3S2)C=CC(F)=C1C(N)=O