Parthenolide

Description: Parthenolide ((-)-Parthenolide) is a natural sesquiterpene lactone that is an NF-kappaB inhibitor and also specifically inhibits HDAC1 protein, but is inactive against other class I/II HDACs. Parthenolide has anti-inflammatory, anti-tumor, and anti-viral activities. Target: Autophagy, Mitophagy, HDAC, Apoptosis, NF-kappaB. Smiles: C\C1=C/CC[C@@]2(C)O[C@H]2[C@H]2OC(=O)C(=C)[C@@H]2CC1. References: Nakshatri, H., Appaiah, H., Anjanappa, M., Gilley, D., Tanaka, H., & Badve, S. et al. (2015). NF-kappaB-dependent and -independent epigenetic modulation using the novel anti-cancer agent DMAPT. Cell Death & Disease, 6(1), e1608-e1608. doi: 10.1038/cddis.2014.569