Paroxetine (hydrochloride)

Paroxetine is a selective serotonin reuptake inhibitor (SSRI, Ki = 0.04 nM). It is selective for the serotonin transporter (SERT) over the dopamine and norepinephrine transporters (Kis = 400 and 90 nM, respectively) as well as the serotonin (5-HT) receptor subtypes 5-HT1A and 5-HT2A, the histamine H1 receptor, alpha1- and alpha2-adrenergic receptors (alpha2-ARs), and muscarinic acetylcholine receptors (mAChRs, Kis = 21,168, 6,320, 13,746, 995, 3,915, and 42 nM, respectively). Paroxetine (5 mg/kg) decreases immobility time in the forced swim test in mice. Formulations containing paroxetine have been used in the treatment of depression, obsessive-compulsive disorder (OCD), panic disorder, social and generalized anxiety disorders, and post-traumatic stress disorder (PTSD).Formal Name: (3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-fluorophenyl)-piperidine, monohydrochloride. CAS Number: 78246-49-8. Synonyms: BRL 29060A. Molecular Formula: C19H20FNO3 . HCl. Formula Weight: 365.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 33 mg/ml, DMF:PBS (pH 7) (1:10): 0.09 mg/ml, DMSO: 20 mg/ml, Ethanol: 20 mg/ml. lambdamax: 235, 265, 271, 295 nm. SMILES: FC1=CC=C([C@H]2[C@H](COC3=CC(OCO4)=C4C=C3)CNCC2)C=C1.Cl. InChi Code: InChI=1S/C19H20FNO3.ClH/c20-15-3-1-13(2-4-15)17-7-8-21-10-14(17)11-22-16-5-6-18-19(9-16)24-12-23-18,/h1-6,9,14,17,21H,7-8,10-12H2,1H/t14-,17-,/m0./s1. InChi Key: GELRVIPPMNMYGS-RVXRQPKJSA-N.