Paraxanthine-d6

Paraxanthine-d6 is intended for use as an internal standard for the quantification of paraxanthine (Cay-21068) by GC- or LC-MS. Paraxanthine is an active metabolite of caffeine (Cay-14118). It is formed via N3-demethylation of caffeine by the cytochrome P450 (CYP) isoform CYP1A2. Paraxanthine is an adenosine A1 and A2 receptor antagonist (Kis = 35 and 22 µM, respectively). In vivo, paraxanthine (30 mg/kg) increases striatal cGMP and extracellular striatal dopamine levels and locomotor activity, as well as inhibits motor depression induced by the adenosine A1 agonist CPA (N6-cyclopentyladenosine, Cay-21448) or the adenosine A2 receptor agonist CGS 21680 (Cay-17126) in rats not habituated to caffeine. It also promotes wakefulness and increases locomotor activity and core temperature in narcoleptic transgenic mice without increasing behavioral anxiety.Formal Name: 3,7-dihydro-1,7-di(methyl-d3)-1H-purine-2,6-dione. CAS Number: 117490-41-2. Synonyms: 1,7-Dimethylxanthine-d6. Molecular Formula: C7H2D6N4O2. Formula Weight: 186.2. Purity: >99% deuterated forms (d1-d6), =1% d0. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: O=C1C2=C(N=CN2C([2H])([2H])[2H])NC(N1C([2H])([2H])[2H])=O. InChi Code: InChI=1S/C7H8N4O2/c1-10-3-8-5-4(10)6(12)11(2)7(13)9-5/h3H,1-2H3,(H,9,13)/i1D3,2D3. InChi Key: QUNWUDVFRNGTCO-WFGJKAKNSA-N. Origin: Synthetic.