Oxaloacetic Acid

Oxaloacetic acid is an alpha-keto acid and a key component of cellular metabolism in its conjugate base form, oxaloacetate. Oxaloacetate reacts with acetyl-coenzyme A (acetyl-CoA, Cay-16160) and water to form citrate in the first step of the citric acid cycle and is regenerated by oxidation of L-malate in the final step. It is an intermediate in gluconeogenesis that is formed in mitochondria via carboxylation of pyruvate and subsequently decarboxylated and phosphorylated to form phosphoenolpyruvate. It can be converted to aspartate via addition of an amino group from glutamate. Oxaloacetate (30 µmol/min per 100 g for 30 minutes, i.v.) reduces blood glutamate levels, severity of neurological dysfunction, and brain edema in a rat model of closed head injury.Formal Name: 2-oxo-butanedioic acid. CAS Number: 328-42-7. Synonyms: NSC 284205, NSC 77688, OAA, Oxalacetic Acid. Molecular Formula: C4H4O5. Formula Weight: 132.1. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: 15mg/mL, DMSO: 15mg/mL, Ethanol: 15mg/mL. lambdamax: 259 nm. SMILES: OC(CC(C(O)=O)=O)=O. InChi Code: InChI=1S/C4H4O5/c5-2(4(8)9)1-3(6)7/h1H2,(H,6,7)(H,8,9). InChi Key: KHPXUQMNIQBQEV-UHFFFAOYSA-N.