ORG 274179-0

Artikelnummer	Größe	Manual	Lieferzeit	Preis
Cay43557-1	1 mg	-	6 - 10 Werktage*	97,00 €
Cay43557-5	5 mg	-	6 - 10 Werktage*	436,00 €
Cay43557-10	10 mg	-	6 - 10 Werktage*	771,00 €
Cay43557-25	25 mg	-	6 - 10 Werktage*	1.446,00 €

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ORG 274179-0 is a thyroid-stimulating hormone receptor (TSHR) allosteric antagonist. It inhibits... mehr

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Produktinformationen "ORG 274179-0"

ORG 274179-0 is a thyroid-stimulating hormone receptor (TSHR) allosteric antagonist. It inhibits TSHR activation induced by bovine TSH, human TSH, or the TSH-receptor-stimulating immunoglobulin M22 in reporter assays using CHO cells expressing the human receptor (IC50s = 30, 26, and 56 nM, respectively). ORG 274179-0 inhibits bovine TSH- or M22-induced phospholipase C (PLC) activation in CHO cells expressing human TSHR (IC50s = 5 and 4 nM, respectively). InChI: InChI=1S/C28H27F3N2O2/c1-19(34)33-16-15-27(2,21-8-4-3-5-9-21)24-18-23(12-13-25(24)33)32-26(35)14-11-20-7-6-10-22(17-20)28(29,30)31/h3-10,12-13,17-18H,11,14-16H2,1-2H3,(H,32,35)/t27-/m0/s1 InChIKey: IOEFWCOWBKDSQX-MHZLTWQESA-N SMILES: O=C(NC(C=C12)=CC=C1N(C(C)=O)CC[C@@]2(C)C3=CC=CC=C3)CCC4=CC(C(F)(F)F)=CC=C4

Schlagworte:	N-[(4S)-1-acetyl-1,2,3,4-tetrahydro-4-methyl-4-phenyl-6-quinolinyl]-3-(trifluoromethyl)-benzenepropanamide
Hersteller:	Cayman Chemical
Hersteller-Nr:	43557

Eigenschaften

Anwendung:	Thyrotropin receptor (TSHR) allosteric antagonist
MW:	480.53 D
Formel:	C28H27F3N2O2
Reinheit:	>98%
Format:	Solid

Datenbank Information

CAS :	1421683-12-6\| Passende Produkte
KEGG ID :	K04249 \| Passende Produkte

Handhabung & Sicherheit

Lagerung:	-20°C
Versand:	-20°C (International: -20°C)
Signalwort:	Warning
GHS-Piktogramme:
H-Sätze:	H302, H315, H319, H335
P-Sätze:	P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501