Orfamide A

Orfamide A is a lipopeptide biosurfactant originally isolated from P. protegens. It induces mortality in adult green peach aphids (LC50 = 34.5 µg/ml). Orfamide A (50 µM) blocks appressoria formation in M. oryzae isolates and reduces the number of sporulating blast lesions in M. oryzae-infected plants. It is also active against T. b. brucei (IC50 = 6 µM).Formal Name: N-(3-hydroxy-1-oxotetradecyl)-L-leucyl-D-alpha-glutamyl-D-allothreonyl-D-alloisoleucyl-L-leucyl-D-seryl-L-leucyl-L-leucyl-D-seryl-L-valine, (10->3)-lactone. CAS Number: 939960-34-6. Molecular Formula: C64H114N10O17. Formula Weight: 1295.7. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMF: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: CC(C)C[C@@H](C(N[C@@H](CC(C)C)C(N[C@@](CO)([H])C(N[C@@H](C(C)C)C(O[C@H](C)[C@H]1NC([C@H](NC([C@H](CC(C)C)NC(CC(O)CCCCCCCCCCC)=O)=O)CCC(O)=O)=O)=O)=O)=O)=O)NC([C@@H](CO)NC([C@@](CC(C)C)([H])NC([C@]([C@H](CC)C)([H])NC1=O)=O)=O)=O. InChi Code: InChI=1S/C64H114N10O17/c1-15-17-18-19-20-21-22-23-24-25-42(77)32-50(78)65-44(28-35(3)4)56(82)66-43(26-27-51(79)80)55(81)74-54-41(14)91-64(90)52(39(11)12)72-61(87)49(34-76)71-58(84)46(30-37(7)8)67-57(83)45(29-36(5)6)68-60(86)48(33-75)70-59(85)47(31-38(9)10)69-62(88)53(40(13)16-2)73-63(54)89/h35-49,52-54,75-77H,15-34H2,1-14H3,(H,65,78)(H,66,82)(H,67,83)(H,68,86)(H,69,88)(H,70,85)(H,71,84)(H,72,87)(H,73,89)(H,74,81)(H,79,80)/t40-,41+,42?,43+,44-,45-,46-,47-,48+,49+,52-,53+,54+/m0/s1. InChi Key: AFOLBAYDTRBYBA-AAYKRXRBSA-N. Origin: Bacterium/Pseudomonas fluorescens.