Ophiobolin A

White solid. Soluble in ethanol, methanol, DMSO or dimethylformamide. Poorly soluble in water. Cell permeable, irreversible calmodulin antagonist. Acts by covalently binding to a lysine-rich inhibitory site. Inhibits by blocking the activation of the Ca2+/calmodulin-dependent phosphodiesterase, Herbicidal mycotoxin, Phytotoxic, antifungal, antibacterial and nematocidal compound, Anticancer compound. Shown to induce paraptosis-like cell death, Shown to inhibit P-glycoprotein-mediated transport.