ONO-8711 (dicyclohexylamine salt)

ONO-8711 is an antagonist of the prostaglandin E2 (PGE2, Cay-14010) receptor subtype EP1 (Kis = 0.6 and 1.7 nM for human and mouse receptors, respectively, expressed in CHO cells). It is selective for EP1 over EP2, EP3, and EP4 (Kis = >1,000, 67, and >1,000 nM, respectively, for mouse receptors expressed in CHO cells). ONO-8711 inhibits PGE2-induced increases in intracellular calcium concentrations in cells expressing human or mouse EP1 (EC50s = 50 and 210 nM, respectively). Dietary administration of ONO-8711 (400 and 800 ppm) reduces the incidence of squamous cell carcinoma and severe dysplasia in a rat model of tongue carcinogenesis induced by 4-nitroquinoline 1-oxide.Formal Name: 6-[(2R,3S)-3-[[[(4-chloro-2-methylphenyl)sulfonyl]amino]methyl]bicyclo[2.2.2]oct-2-yl]-5Z-hexenoic acid, dicyclohexylamine salt. Molecular Formula: C22H30ClNO4S . C12H23N. Formula Weight: 621.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 10 mg/ml. SMILES: ClC1=CC(C)=C(S(NC[C@@H](C2CCC3CC2)[C@H]3/C=C\CCCC(O)=O)(=O)=O)C=C1.C4(NC5CCCCC5)CCCCC4. InChi Code: InChI=1S/C22H30ClNO4S.C12H23N/c1-15-13-18(23)11-12-21(15)29(27,28)24-14-20-17-9-7-16(8-10-17)19(20)5-3-2-4-6-22(25)26,1-3-7-11(8-4-1)13-12-9-5-2-6-10-12/h3,5,11-13,16-17,19-20,24H,2,4,6-10,14H2,1H3,(H,25,26),11-13H,1-10H2/b5-3-,/t16?,17?,19-,20-,/m0./s1. InChi Key: LLFSWESJGDSALX-YBAOTWTCSA-N.