Ombitasvir

Description: Ombitasvir (ABT-267) is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A).with EC50s of 0.82 to 19.3 pM against HCV genotypes 1 to 5, and 366 pM against genotype 6a. Target: HCV Protease. Smiles: COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@]1(C(N)=O)c1ccc(cc1)[C@@H]1CC[C@H](N1c1ccc(cc1)C(C)(C)C)c1ccc(cc1)[C@]1(CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C(N)=O. References: Krishnan P, Beyer J, Mistry N,et al.in vitro and in vivo antiviral activity and resistance profile of ombitasvir, an inhibitor of hepatitis c virus ns5a[J].Antimicrob Agents Chemother. 2015 Feb,59(2):979-87.