Oleic Acid-2,6-diisopropylanilide

AcylCoA:cholesterol acyltransferase (ACAT) is an intracellular cholesteryl ester synthase tied closely to the absorption of dietary cholesterol. Oleic acid-2,6-diisopropylanilide is an inhibitor of acylCoA:cholesterol acyltransferase with an IC50 of 7 nM. When co-administered to rabbits or rats fed a high fat, high cholesterol diet, oleic acid-2,6-diisopropylanilide decreased low density lipoproteins and elevated high density lipoprotein levels when administered at 0.05%.Formal Name: N-[2,6-bis(1-methylethyl)phenyl]-9Z-octadecenamide. CAS Number: 140112-65-8. Molecular Formula: C30H51NO. Formula Weight: 441.7. Purity: >98%. Formulation: (Request formulation change), A solution in methyl acetate. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml, PBS (pH 7.2): 1 mg/ml. SMILES: CC(C)C1=C(N([H])C(CCCCCCC/C=C\CCCCCCCC)=O)C(C(C)C)=CC=C1. InChi Code: InChI=1S/C30H51NO/c1-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-24-29(32)31-30-27(25(2)3)22-21-23-28(30)26(4)5/h13-14,21-23,25-26H,6-12,15-20,24H2,1-5H3,(H,31,32)/b14-13-. InChi Key: KIULGBCXKSTGQP-YPKPFQOOSA-N.