Ogerin

Description: Ogerin is a selective GPR68 positive allosteric modulator (pEC50: 6.83) that blocks recall in fear conditioning in mice. It exhibits inverse agonist and antagonist activity (Ki, 220 nM) at the A2A receptor and weak antagonist activity (Ki, 736 nM) at the 5-HT2B receptor. Target: 5-HT Receptor, Adenosine Receptor, Others. Smiles: Nc1nc(NCc2ccccc2)nc(n1)-c1ccccc1CO. References: Huang XP, et al. Allosteric ligands for the pharmacologically dark receptors GPR68 and GPR65. Nature. 2015 Nov 26,527(7579):477-83.