Ogerin

Ogerin is a positive allosteric modulator of G protein-coupled receptor 68 (GPR68). It increases proton-induced cAMP production in HEK293T cells expressing the human receptor in a reporter assay. Ogerin inhibits proton-mediated calcium release in the same cells when used at a concentration of 10 µM. It impairs contextual, but not cued, fear conditioning in wild-type, but not Gpr68 knockout, mice when administered at a dose of 10 mg/kg.Formal Name: 2-[4-amino-6-[(phenylmethyl)amino]-1,3,5-triazin-2-yl]-benzenemethanol. CAS Number: 1309198-71-7. Synonyms: ZINC67740571. Molecular Formula: C17H17N5O. Formula Weight: 307.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: 50 mg/ml. SMILES: OCC1=C(C2=NC(N)=NC(NCC3=CC=CC=C3)=N2)C=CC=C1. InChi Code: InChI=1S/C17H17N5O/c18-16-20-15(14-9-5-4-8-13(14)11-23)21-17(22-16)19-10-12-6-2-1-3-7-12/h1-9,23H,10-11H2,(H3,18,19,20,21,22). InChi Key: MDGIEDNDSFMSLP-UHFFFAOYSA-N.