NU 9056

NU 9056 was originally identified as an inhibitor of TIP60, also known as lysine acetyltransferase 5 (KAT5, IC50 = 2 µM). However, it has been shown that NU 9056 is thiol-reactive in a cell-free assay and inhibits multiple targets in biochemical and cell-based assays, indicating it is a non-selective interference compound. NU 9056 inhibits the growth of LNCaP, CWR22Rupsilon1, and PC3 prostate cancer cells (GI50s = 24, 7. and 27 µM, respectively) and induces apoptosis in LNCaP cells. It inhibits activation of the NOD-like receptor protein 3 (NLRP3) inflammasome in LPS-primed nigericin-induced primary mouse peritoneal macrophages. NU 9056 (10 mg/kg) decreases lung injury in a mouse model of LPS-induced endotoxemia. It increases freezing time seven days after fear conditioning, indicating enhanced remote memory, in mice when administered at a dose of 2 µg/g. Formal Name: 5,5'-dithiobis-isothiazole. CAS Number: 1450644-28-6. Molecular Formula: C6H4N2S4. Formula Weight: 232.4. Purity: >85%. Formulation (Request formulation change): A liquid. Solubility: DMSO: Soluble: >10 mg/ml Ethanol: Soluble: >10 mg/ml. SMILES: C1(SSC2=CC=NS2)=CC=NS1. InChi Code: InChI=1S/C6H4N2S4/c1-3-7-9-5(1)11-12-6-2-4-8-10-6/h1-4H. InChi Key: MLRAMCAHIWHWRM-UHFFFAOYSA-N. Storage: -20°C. Stability: > 4 years.