NSC 5844

NSC 5844 is a bis-quinoline with diverse biological activities. It inhibits the growth of P. falciparum strains that are sensitive (D-6) and resistant (W-2) to chloroquine (Cay-14194) in vitro (IC50s = 17 and 27 nM, respectively) but lacks activity against P. berghei in vivo. NSC 5844 inhibits the growth of MDA-MB-468 and MCF-7 breast cancer cells with GI50 values of 7.35 and 14.80 µM, respectively. It also inhibits 24% of botulinum neurotoxin serotype A light chain (BoNT/A LC) metalloprotease activity at a concentration of 20 µM.Formal Name: N1,N2-bis(7-chloro-4-quinolinyl)-1,2-ethanediamine. CAS Number: 140926-75-6. Molecular Formula: C20H16Cl2N4. Formula Weight: 383.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.33 mg/ml, DMSO: 0.25 mg/ml, Ethanol: Slightly soluble. lambdamax: 219, 254, 336 nm. SMILES: ClC1=CC=C(C(NCCNC2=CC=NC3=C2C=CC(Cl)=C3)=CC=N4)C4=C1. InChi Code: InChI=1S/C20H16Cl2N4/c21-13-1-3-15-17(5-7-23-19(15)11-13)25-9-10-26-18-6-8-24-20-12-14(22)2-4-16(18)20/h1-8,11-12H,9-10H2,(H,23,25)(H,24,26). InChi Key: SSXYXSMMVMVYEV-UHFFFAOYSA-N.