NSC 348884

Nucleophosmin is a nucleolar phosphoprotein involved in cell proliferation, cytoplasmic/nuclear shuttle transportation, nucleic acid binding, ribonucleic cleavage, centrosome duplication, and molecular chaperoning. Its activity is dependent on oligomerization at its N-terminal domain, and it is abundantly expressed in tumor and developing cells where it serves to inhibit both cellular differentiation and apoptosis. NSC 348884 is a small molecule that inhibits the formation of nucleophosmin dimers by disrupting a required binding pocket. It can inhibit cell proliferation and induce apoptosis in various cancer cell lines with IC50 values ranging from 1.4-4 µM.Formal Name: N1,N1,N2,N2-tetrakis[(6-methyl-1H-benzimidazol-2-yl)methyl]-1,2-ethanediamine. CAS Number: 81624-55-7. Molecular Formula: C38H40N10. Formula Weight: 636.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS(pH7.2) (1:2): 0.25 mg/ml, DMSO: 10 mg/ml, Ethanol: 1 mg/ml. lambdamax: 247, 281, 287 nm. SMILES: CC(C=C1)=CC2=C1NC(CN(CC3=NC(C=CC(C)=C4)=C4N3)CCN(CC5=NC6=C(C=C(C)C=C6)N5)CC7=NC(C=CC(C)=C8)=C8N7)=N2. InChi Code: InChI=1S/C38H40N10/c1-23-5-9-27-31(15-23)43-35(39-27)19-47(20-36-40-28-10-6-24(2)16-32(28)44-36)13-14-48(21-37-41-29-11-7-25(3)17-33(29)45-37)22-38-42-30-12-8-26(4)18-34(30)46-38/h5-12,15-18H,13-14,19-22H2,1-4H3,(H,39,43)(H,40,44)(H,41,45)(H,42,46). InChi Key: KZOLQEUQAFTQFM-UHFFFAOYSA-N.