NQ301

NQ301 is a naphthoquinone with diverse biological activities, including antiplatelet, antithrombotic, anti-inflammatory, and antimicrobial properties. It inhibits rabbit platelet aggregation induced by the thromboxane A2 receptor agonist U-46619 (Cay-16450) in vitro (IC50 = 0.58 µM) and inhibits the conversion of arachidonic acid to thromboxane B2 in rabbit platelets in a concentration-dependent manner. It also inhibits human platelet aggregation induced by ADP, collagen, epinephrine, and the calcium ionophore A23187 in vitro (IC50s = 3.21, 15.69, 8.44, and 44.2 µM, respectively). NQ301 (50 and 100 mg/kg) increases tail bleeding time and exhibits a protective effect against pulmonary thrombosis in mice. It inhibits the protein tyrosine phosphatase CD45 with an IC50 value of 0.29 µM. NQ301 (3 mg/kg) inhibits ovalbumin-induced footpad swelling in a mouse model of delayed-type hypersensitivity. It is also active against C. albicans, A. niger, B. subtilis, S. aureus, E. coli, and P. aeruginosa (MICs = 12.5-50 µg/ml).Formal Name: 2-[(4-acetylphenyl)amino]-3-chloro-1,4-naphthalenedione. CAS Number: 130089-98-4. Molecular Formula: C18H12ClNO3. Formula Weight: 325.8. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMSO: 14 mg/ml, Ethanol: 2 mg/ml. lambdamax: 233, 305, 474 nm. SMILES: O=C(C(Cl)=C1NC2=CC=C(C(C)=O)C=C2)C3=CC=CC=C3C1=O. InChi Code: InChI=1S/C18H12ClNO3/c1-10(21)11-6-8-12(9-7-11)20-16-15(19)17(22)13-4-2-3-5-14(13)18(16)23/h2-9,20H,1H3. InChi Key: LSQZKIQSQHZVQS-UHFFFAOYSA-N.