Nocardamine

Nocardamine is a ferrioxamine siderophore that has been found in Streptomyces and has diverse biological activities. It chelates iron in a chrome azurol S assay (IC50 = 9.9 µM). Nocardamine inhibits M. smegmatis and M. bovis biofilm formation (MIC = 10 µM for both), an effect that can be reversed by iron. It is cytotoxic to T47D, SK-MEL-5, SK-MEL-28, and RPMI-7951 cancer cells (IC50s = 6, 18, 12, and 14 µM, respectively). Nocardamine also induces morphological changes in BM-N4 insect cells.Formal Name: 1,12,23-trihydroxy-1,6,12,17,23,28-hexaazacyclotritriacontane-2,5,13,16,24,27-hexone. CAS Number: 26605-16-3. Synonyms: Desferrioxamine E, Proferrioxamine E. Molecular Formula: C27H48N6O9. Formula Weight: 600.7. Purity: >70%. Formulation: (Request formulation change), A solid. Solubility: Dichloromethane: soluble, DMSO: soluble, Ethanol: soluble, Methanol: soluble. SMILES: O=C(CCC(N(O)CCCCCNC(CCC1=O)=O)=O)NCCCCCN(O)C(CCC(NCCCCCN1O)=O)=O. InChi Code: InChI=1S/C27H48N6O9/c34-22-10-14-26(38)32(41)20-8-3-6-18-30-24(36)12-15-27(39)33(42)21-9-2-5-17-29-23(35)11-13-25(37)31(40)19-7-1-4-16-28-22/h40-42H,1-21H2,(H,28,34)(H,29,35)(H,30,36). InChi Key: NHKCCADZVLTPPO-UHFFFAOYSA-N. Origin: Bacterium/Streptomyces sp..