Nilotinib, Free Base (4-methyl-N-[3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl]-3-[(4-pyridin

Nilotinib, a novel, selective BCR-ABL inhibitor, fits into the ATP-binding site of the BCR-ABL protein with higher affinity than imatinib. Nilotinib is not only more potent than imatinib against wild-type BCR-ABL (IC50 < 30nM), but also significantly active against 32/33 imatinib-resistant BCR-ABL mutants. Melting Point: 242.5-245ºC, Solubility: Soluble in DMSO at 50mg/ml, very poorly soluble in ethanol, very poorly soluble in water, maximum solubility in plain water is estimated to be about 10-20uM, buffers, serum, or other additives may increase or decrease the aqueous solubility. Elemental Analysis: Calculated, C - 63.51%, H - 4.19%, F - 10.76%, N - 18.52%, Storage and Stability: May be stored at RT for short-term only. Long-term storage is recommended at -20°C. For maximum recovery of product, centrifuge the original vial prior to removing the cap.