NG,NG-dimethyl-L-Arginine-d6 (hydrochloride)

NG,NG-dimethyl-L-arginine-d6 (ADMA-d6) (hydrochloride) is intended for use as an internal standard for the quantification of NG,NG-dimethyl-L-arginine (Cay-80230) by GC- or LC-MS. ADMA is an endogenous inhibitor of nitric oxide synthase (NOS). It is formed from arginine by protein arginine methyltransferases (PRMTs) and degraded by dimethylarginine dimethylaminohydrolases (DDAHs) and alanine-glyoxylate aminotransferase 2 (AGXT2). ADMA levels are increased concomitant with an increase in blood pressure in Dahl salt-sensitive rats fed a high-salt diet. ADMA levels are increased in the plasma in a variety of endothelial dysfunction-related diseases, including hypertension, congestive heart failure, and end-stage renal disease. InChI: InChI=1S/C8H18N4O2.2ClH/c1-12(2)8(10)11-5-3-4-6(9)7(13)14,,/h6H,3-5,9H2,1-2H3,(H2,10,11)(H,13,14),2*1H/t6-,,/m0../s1/i1D3,2D3,,, InChIKey: SYLNVYJOPZWPJI-WTPXGJEESA-N, SMILES: [2H]C([2H])([2H])N(C([2H])([2H])[2H])C(NCCC[C@H](N)C(O)=O)=N.Cl.Cl