NFATc1 Inhibitor A04

NFATc1 inhibitor A04 is an inhibitor of nuclear factor of activated T cells c1 (NFATc1). It inhibits RANKL-induced nuclear translocation of NFATc1 in RAW 264.7 cells when used at concentrations of 1.5 or 2 µM. NFATc1 inhibitor A04 reduces RANKL-induced differentiation of RAW 264.7 cells into osteoclasts (IC50 = 1.57 µM).Formal Name: 5-fluoro-N-(2-fluoro-4-iodophenyl)-2-hydroxy-benzamide. CAS Number: 1912422-56-0. Synonyms: Nuclear Factor of Activated T cells c1 Inhibitor A04. Molecular Formula: C13H8F2INO2. Formula Weight: 375.1. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: :, DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly soluble: 1-10 mg/ml. SMILES: FC1=CC=C(O)C(C(NC2=CC=C(C=C2F)I)=O)=C1. InChi Code: InChI=1S/C13H8F2INO2/c14-7-1-4-12(18)9(5-7)13(19)17-11-3-2-8(16)6-10(11)15/h1-6,18H,(H,17,19). InChi Key: IGRCFOGPIJEESA-UHFFFAOYSA-N.