NF-kappaB Activation Inhibitor III

NF-kappaB activation inhibitor III is an inhibitor of NF-kappaB activation. NF-kappaB activation inhibitor III (20 µM) inhibits TNF-alpha-induced NF-kappaB activation in HT-1080 fibrosarcoma cells. NF-kappaB activation inhibitor III inhibits TNF-alpha-induced expression of the gene encoding matrix metalloproteinase-9 (MMP-9) in HT-1080 cells in a concentration-dependent manner and decreases TNF-alpha-induced migration of HT-1080 cells. It inhibits IL-6 release induced by TNF-alpha from primary rat brain pericytes when used at concentrations of 1, 5, and 10 µM. NF-kappaB activation inhibitor III (5 µM) increases IL-8 secretion in HT-29 and Caco-2 colon cancer cells when used in combination with glyoxal.Formal Name: 3-chloro-4-nitro-N-(5-nitro-2-thiazolyl)-benzamide. CAS Number: 380623-76-7. Synonyms: SM-7368. Molecular Formula: C10H5ClN4O5S. Formula Weight: 328.7. Purity: >99%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble. SMILES: ClC1=C([N+]([O-])=O)C=CC(C(NC2=NC=C([N+]([O-])=O)S2)=O)=C1. InChi Code: InChI=1S/C10H5ClN4O5S/c11-6-3-5(1-2-7(6)14(17)18)9(16)13-10-12-4-8(21-10)15(19)20/h1-4H,(H,12,13,16). InChi Key: XCHLNGBTHLJLFG-UHFFFAOYSA-N.