Neuropathiazol

Neuropathiazol is an inducer of neuronal differentiation. It induces differentiation of primary rat hippocampal neural progenitor cells when used at a concentration of 10 µM. Neuropathiazol (20 mg/kg per day), alone and in combination with cyclophosphamide (Cay-13849), decreases tumor volume in an SK-N-AS neuroblastoma mouse xenograft model. It increases intratumoral levels of neuronatin, microtubule-associated protein 2 (MAP2), and neurofilament light polypeptide (NF-L), markers of differentiation, in the same model. InChI: InChI=1S/C19H18N2O2S/c1-3-23-19(22)15-9-11-16(12-10-15)21(2)17-13-24-18(20-17)14-7-5-4-6-8-14/h4-13H,3H2,1-2H3 InChIKey: MGKYEWWFHSESJN-UHFFFAOYSA-N SMILES: O=C(C1=CC=C(N(C)C2=CSC(C3=CC=CC=C3)=N2)C=C1)OCC