Netilimicin (sulfate)

Netilimicin is an aminoglycoside antibiotic. It is active against S. aureus, N. gonorrhoeae, E. coli, P. mirabilis, and P. aeruginosa (MICs = 0.4, 3.1, 0.8, 1.6, and 0.4 µg/ml, respectively) as well as Enterococci, Enterobacter, Citrobacter, and Klebsiella species (MICs = 3.1, 0.4, 0.8, and =0.2 µg/ml, respectively). Netilimicin induces nephrotoxicity in rats when administered at doses ranging from 50 to 150 mg/kg. It also induces neuromuscular block, decreasing twitch tension in isolated diaphragm and soleus muscles in rabbits (ED50s = 18.5 and 62.2 mg/kg, respectively). Formulations containing netilimicin were previously used in the intravenous treatment of severe bacterial infections.Formal Name: O-3-deoxy-4-C-methyl-3-(methylamino)-beta-L-arabinopyranosyl-(1->6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-alpha-D-glycero-hex-4-enopyranosyl-(1->4)]-2-deoxy-N1-ethyl-D-streptamine, sulfate (2:5). CAS Number: 56391-57-2. Synonyms: Netillin, Netilyn. Molecular Formula: C21H41N5O7 . 2.5H2SO4. Formula Weight: 720.8. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 10 mg/ml. SMILES: N[C@H]1[C@](O[C@@H]2[C@@H](N)C[C@@H](NCC)[C@H](O[C@]3([H])[C@H](O)[C@@H](NC)[C@@](C)(O)CO3)[C@H]2O)([H])OC(CN)=CC1.OS(O)(=O)=O.OS(O)(=O)=O.OS(O)(=O)=O. InChi Code: InChI=1S/C21H41N5O7.3H2O4S/c1-4-26-13-7-12(24)16(32-19-11(23)6-5-10(8-22)31-19)14(27)17(13)33-20-15(28)18(25-3)21(2,29)9-30-20,3*1-5(2,3)4/h5,11-20,25-29H,4,6-9,22-24H2,1-3H3,3*(H2,1,2,3,4)/t11-,12+,13-,14+,15-,16-,17+,18-,19-,20-,21+,,,/m1.../s1. InChi Key: MADCIBJSLWDZDF-JPAWNEMXSA-N.