Nepsilon-(1-Carboxyethyl)-L-lysine

Nepsilon-(1-Carboxyethyl)-L-lysine (CEL) is an advanced glycation end product (AGE) produced by the reaction of methyl glyoxal with lysine residues in proteins. Protein bound, but not free, CEL binds to the receptor for AGEs (RAGE). CEL levels are elevated in the lens of diabetic patients with cataract. Long-term caloric restriction decreases CEL levels in rat heart mitochondria. It decreases glutamate uptake and secretion of S100B in rat hippocampal slices in a RAGE-independent manner when used at a concentration of 1 mM.Formal Name: N6-(1-carboxyethyl)-L-lysine. CAS Number: 5746-03-2. Synonyms: CEL. Molecular Formula: C9H18N2O4. Formula Weight: 218.3. Purity: >95% (mixture of diastereomers). Formulation: (Request formulation change), A solid. Solubility: Water: Slightly Soluble. SMILES: OC(C(NCCCC[C@H](N)C(O)=O)C)=O. InChi Code: InChI=1S/C9H18N2O4/c1-6(8(12)13)11-5-3-2-4-7(10)9(14)15/h6-7,11H,2-5,10H2,1H3,(H,12,13)(H,14,15)/t6?,7-/m0/s1. InChi Key: XCYPSOHOIAZISD-MLWJPKLSSA-N.