Neohesperidin

Neohesperidin is a flavonoid found in citrus fruit peel that has diverse biological activities. In vitro, it inhibits osteoclast differentiation, bone resorption, calcium oscillations, and activation of NF-kappaB and nuclear factor of activated T cells (NFAT) by receptor activator of NF-kappaB ligand (RANKL). In vivo, neohesperidin administration protects ovariectomized mice from bone loss. Neohesperidin acts as a hypolipidemic agent, reducing lipid accumulation in HepG2 cells and reversing hyperlipidemia in a mouse model of diet-induced obesity. In a mouse model of diabetes, neohesperidin increases glucose tolerance and decreases insulin resistance while simultaneously decreasing serum triglycerides and total cholesterol and inhibiting lipid accumulation in livers in vivo.Formal Name: (2S)-7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2,3-dihydro-5-hydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-1-benzopyran-4-one. CAS Number: 13241-33-3. Synonyms: Hesperetin 7-neohesperidoside, NSC 31048. Molecular Formula: C28H34O15. Formula Weight: 610.6. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 3 mg/ml, DMSO: 5 mg/ml, DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml. lambdamax: 285 nm. SMILES: O=C1C2=C(O)C=C(O[C@H]3[C@H](O[C@@]4([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O4)[C@@H](O)[C@H](O)[C@@H](CO)O3)C=C2O[C@H](C5=CC=C(OC)C(O)=C5)C1. InChi Code: InChI=1S/C28H34O15/c1-10-21(33)23(35)25(37)27(39-10)43-26-24(36)22(34)19(9-29)42-28(26)40-12-6-14(31)20-15(32)8-17(41-18(20)7-12)11-3-4-16(38-2)13(30)5-11/h3-7,10,17,19,21-31,33-37H,8-9H2,1-2H3/t10-,17-,19+,21-,22+,23+,24-,25+,26+,27-,28+/m0/s1. InChi Key: ARGKVCXINMKCAZ-UZRWAPQLSA-N.