Neoeriocitrin

Neoeriocitrin is a flavonoid that has been found in C. paradisi and has antioxidative and osteogenic activities. It inhibits the production of 2,2-diphenyl-1-picrylhydrazyl (DPPH, Cay-14805) radicals by 17.2% and the formation of superoxide radicals by 48.3% in cell-free assays, as well as decreases the rate of LDL oxidation ex vivo in isolated hamster plasma. Neoeriocitrin (2 µg/ml) increases proliferation of MC3T3-E1 osteoblast percursor cells and reverses the antiproliferative effect of the MEK1 inhibitor PD 98059 (Cay-10006726). It also increases the expression of the osteogenic differentiation markers Runx2, Type 1 collagen, and osteocalcin.Formal Name: (2S)-7-[[2-O-(6-deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]oxy]-2-(3,4-dihydroxyphenyl)-2,3-dihydro-5-hydroxy-4H-1-benzopyran-4-one. CAS Number: 13241-32-2. Synonyms: Eriodictyol 7-O-neohesperidoside. Molecular Formula: C27H32O15. Formula Weight: 596.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMSO: 30 mg/ml, DMSO:PBS(pH 7.2) (1:4): 0.2 mg.ml, Ethanol: 1 mg/ml. lambdamax: 285 nm. SMILES: O[C@H]1[C@H](O)[C@@H](CO)O[C@@H](OC2=CC(O)=C(C(C[C@@H](C3=CC=C(O)C(O)=C3)O4)=O)C4=C2)[C@@H]1O[C@@]5([H])[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O5. InChi Code: InChI=1S/C27H32O15/c1-9-20(33)22(35)24(37)26(38-9)42-25-23(36)21(34)18(8-28)41-27(25)39-11-5-14(31)19-15(32)7-16(40-17(19)6-11)10-2-3-12(29)13(30)4-10/h2-6,9,16,18,20-31,33-37H,7-8H2,1H3/t9-,16-,18+,20-,21+,22+,23-,24+,25+,26-,27+/m0/s1. InChi Key: OBKKEZLIABHSGY-DOYQYKRZSA-N. Origin: Plant/Aurantii fructus immaturus.